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Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Publication type

Journal Article

Authors

  1. Evangelos Evangelou
  2. Helen R. Warren
  3. David Mosen-Ansorena
  4. Borbala Mifsud
  5. Raha Pazoki
  6. He Gao
  7. Georgios Ntritsos
  8. Niki Dimou
  9. Claudia P. Cabrera
  10. Ibrahim Karaman
  11. Fu Liang Ng
  12. Marina Evangelou
  13. Katarzyna Witkowska
  14. Evan Tzanis
  15. Jacklyn N. Hellwege
  16. Ayush Giri
  17. Digna R. Velez Edwards
  18. Yan V. Sun
  19. Kelly Cho
  20. J. Michael Gaziano
  21. Peter W. F. Wilson
  22. Philip S. Tsao
  23. Csaba P. Kovesdy
  24. Tonu Esko
  25. Reedik Magi
  26. Lili Milani
  27. Peter Almgren
  28. Thibaud Boutin
  29. Stephanie Debette
  30. Jun Ding
  31. Franco Giulianini
  32. Elizabeth G. Holliday
  33. Anne U. Jackson
  34. Ruifang Li-Gao
  35. Wei-Yu Lin
  36. Jian'an Luan
  37. Massimo Mangino
  38. Christopher Oldmeadow
  39. Bram Prins
  40. Yong Qian
  41. Muralidharan Sargurupremraj
  42. Nabi Shah
  43. Praveen Surendran
  44. Sebastien Theriault
  45. Niek Verweij
  46. Sara M. Willems
  47. Jing-Hua Zhao
  48. Philippe Amouyel
  49. John Connell
  50. Renee de Mutsert
  51. Alex S. F. Doney
  52. Martin Farrall
  53. Cristina Menni
  54. Andrew D. Morris
  55. Raymond Noordam
  56. Guillaume Pare
  57. Neil R. Poulter
  58. Denis C. Shields
  59. Alice Stanton
  60. Simon Thom
  61. Goncalo Abecasis
  62. Najaf Amin
  63. Dan E. Arking
  64. Kristin L. Ayers
  65. Caterina M. Barbieri
  66. Chiara Batini
  67. Joshua C. Bis
  68. Tineka Blake
  69. Murielle Bochud
  70. Michael Boehnke
  71. Eric Boerwinkle
  72. Dorret I. Boomsma
  73. Erwin Bottinger
  74. Peter S. Braund
  75. Marco Brumat
  76. Archie Campbell
  77. Harry Campbell
  78. Aravinda Chakravarti
  79. John C. Chambers
  80. Ganesh Chauhan
  81. Marina Ciullo
  82. Massimiliano Cocca
  83. Francis Collins
  84. Heather J. Cordell
  85. Gail Davies
  86. Martin H. de Borst
  87. Eco de Geus
  88. Ian Deary
  89. Joris Deelen
  90. Fabiola M. Del Greco
  91. Cumhur Y. Demirkale
  92. Marcus Dorr
  93. Georg B. Ehret
  94. Roberto Elosua
  95. Stefan Enroth
  96. A. Mesut Erzurumluoglu
  97. Teresa Ferreira
  98. Mattias Franberg
  99. Oscar H. Franco
  100. Ilaria Gandin
  101. Paolo Gasparini
  102. Vilmantas Giedraitis
  103. Christian Gieger
  104. Giorgia Girotto
  105. Anuj Goel
  106. Alan J. Gow
  107. Vilmundur Gudnason
  108. Xiuqing Guo
  109. Ulf Gyllensten
  110. Anders Hamsten
  111. Tamara B. Harris
  112. Sarah E. Harris
  113. Catharina A. Hartman
  114. Aki S. Havulinna
  115. Andrew A. Hicks
  116. Edith Hofer
  117. Albert Hofman
  118. Jouke-Jan Hottenga
  119. Jennifer E. Huffman
  120. Shih-Jen Hwang
  121. Erik Ingelsson
  122. Alan James
  123. Rick Jansen
  124. Marjo-Riitta Jarvelin
  125. Roby Joehanes
  126. Asa Johansson
  127. Andrew D. Johnson
  128. Peter Joshi
  129. Pekka Jousilahti
  130. J. Wouter Jukema
  131. Antti M. Jula
  132. Mika Kahonen
  133. Sekar Kathiresan
  134. Bernard D. Keavney
  135. Kay-Tee Khaw
  136. Paul Knekt
  137. Joanne Knight
  138. Ivana Kolcic
  139. Jaspal S. Kooner
  140. Seppo Koskinen
  141. Kati Kristiansson
  142. Zoltan Kutalik
  143. Maris Laan
  144. Marty Larson
  145. Lenore J. Launer
  146. Benjamin Lehne
  147. Terho Lehtimaki
  148. Daniel Levy
  149. David C. M. Liewald
  150. Li Lin
  151. Lars Lind
  152. Cecilia M. Lindgren
  153. Yongmei Liu
  154. Ruth J. F. Loos
  155. Lorna M. Lopez
  156. Lingchan Lu
  157. Leo-Pekka Lyytikainen
  158. Anubha Mahajan
  159. Chrysovalanto Mamasoula
  160. Jaume Marrugat
  161. Jonathan Marten
  162. Yuri Milaneschi
  163. Anna Morgan
  164. Andrew P. Morris
  165. Alanna C. Morrison
  166. Mike A. Nalls
  167. Priyanka Nandakumar
  168. Christopher P. Nelson
  169. Christopher Newton-Cheh
  170. Teemu Niiranen
  171. Ilja M. Nolte
  172. Teresa Nutile
  173. Albertine J. Oldehinkel
  174. Ben A. Oostra
  175. Paul F. O'Reilly
  176. Elin Org
  177. Sandosh Padmanabhan
  178. Walter Palmas
  179. Arno Palotie
  180. Alison Pattie
  181. Brenda W. J. H. Penninx
  182. Markus Perola
  183. Peter J. Munson
  184. Annette Peters
  185. Ozren Polasek
  186. Peter P. Pramstaller
  187. Nguyen Quang Tri
  188. Olli T. Raitakari
  189. Meixia Ren
  190. Rainer Rettig
  191. Kenneth Rice
  192. Paul M. Ridker
  193. Janina S. Reid
  194. Harriette Riese
  195. Samuli Ripatti
  196. Antonietta Robino
  197. Lynda M. Rose
  198. Jerome I. Rotter
  199. Igor Rudan
  200. Daniella Ruggiero
  201. Yasaman Saba
  202. Cinzia F. Sala
  203. Veikko Salomaa
  204. Nilesh J. Samani
  205. Antti-Pekka Sarin
  206. Rheinhold Schmidt
  207. Helena Schmidt
  208. Nick Shrine
  209. David Siscovick
  210. Albert V. Smith
  211. Harold Schneider
  212. Siim Sober
  213. Rossella Sorice
  214. John M. Starr
  215. David J. Stott
  216. David P. Strachan
  217. Rona J. Strawbridge
  218. Johan Sundstrom
  219. Morris A. Swertz
  220. Kent D. Taylor
  221. Alexander Teumer
  222. Martin D. Tobin
  223. Daniela Toniolo
  224. Michela Traglia
  225. Stella Trompet
  226. Jaakko Tuomilehto
  227. Christophe Tzourio
  228. Andre G. Uitterlinden
  229. Ahmad Vaez
  230. Peter J. van der Most
  231. Cornelia M. van Duijn
  232. Anne-Claire Vergnaud
  233. Germaine C. Verwoert
  234. Veronique Vitart
  235. Uwe Volker
  236. Peter Vollenweider
  237. Dragana Vuckovic
  238. Hugh Watkins
  239. Sarah H. Wild
  240. Gonneke Willemsen
  241. James F. Wilson
  242. Alan F. Wright
  243. Jie Yao
  244. Tatijana Zemunik
  245. Weihua Zhang
  246. John R. Attia
  247. Adam S. Butterworth
  248. Daniel I. Chasman
  249. David Conen
  250. Francesco Cucca
  251. John Danesh
  252. Caroline Hayward
  253. Joanna M. M. Howson
  254. Markku Laakso
  255. Edward G. Lakatta
  256. Claudia Langenberg
  257. Ollie Melander
  258. Dennis O. Mook-Kanamori
  259. Patricia B. Munroe
  260. Colin N. A. Palmer
  261. Lorenz Risch
  262. Robert A. Scott
  263. Rodney J. Scott
  264. Peter Sever
  265. Timothy D. Spector
  266. Pim van der Harst
  267. Nicholas J. Wareham
  268. Eleftheria Zeggini
  269. Morris J. Brown
  270. Andres Metspalu
  271. Adriana M. Hung
  272. Christopher O'Donnell
  273. Todd L. Edwards
  274. Bruce M. Psaty
  275. Ioanna Tzoulaki
  276. Michael R. Barnes
  277. Louise V. Wain
  278. Paul Elliott
  279. Mark J. Caulfield

Publication date

October 11, 2017

Summary

High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.

DOI

https://doi.org/10.1101/198234

Subjects

Notes

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.


Related Publications

  • Genetic analysis of over one million people identifies 535 novel loci for blood pressure

    Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N. Hellwege, Ayush Giri, Digna R. Velez Edwards, Yan V. Sun, Kelly Cho, J. Michael Gaziano, Peter W. F. Wilson, Philip S. Tsao, Csaba P. Kovesdy, Tonu Esko, Reedik Magi, Lili Milani, Peter Almgren, Thibaud Boutin, Stephanie Debette, Jun Ding, Franco Giulianini, Elizabeth G. Holliday, Anne U. Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sebastien Theriault, Niek Verweij, Sara M. Willems, Jing-Hua Zhao, Philippe Amouyel, John Connell, Renee de Mutsert, Alex S. F. Doney, Martin Farrall, Cristina Menni, Andrew D. Morris, Raymond Noordam, Guillaume Pare, Neil R. Poulter, Denis C. Shields, Alice Stanton, Simon Thom, Goncalo Abecasis, Najaf Amin, Dan E. Arking, Kristin L. Ayers, Caterina M. Barbieri, Chiara Batini, Joshua C. Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I. Boomsma, Erwin Bottinger, Peter S. Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J. Cordell, Gail Davies, Martin H. de Borst, Eco de Geus, Ian Deary, Joris Deelen, Fabiola M. Del Greco, Cumhur Y. Demirkale, Marcus Dorr, Georg B. Ehret, Roberto Elosua, Stefan Enroth, A. Mesut Erzurumluoglu, Teresa Ferreira, Mattias Franberg, Oscar H. Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J. Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Sarah E. Harris, Catharina A. Hartman, Aki S. Havulinna, Andrew A. Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E. Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Asa Johansson, Andrew D. Johnson, Peter Joshi, Pekka Jousilahti, J. Wouter Jukema, Antti M. Jula, Mika Kahonen, Sekar Kathiresan, Bernard D. Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S. Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J. Launer, Benjamin Lehne, Terho Lehtimaki, Daniel Levy, David C. M. Liewald, Li Lin, Lars Lind, Cecilia M. Lindgren, Yongmei Liu, Ruth J. F. Loos, Lorna M. Lopez, Lingchan Lu, Leo-Pekka Lyytikainen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P. Morris, Alanna C. Morrison, Mike A. Nalls, Priyanka Nandakumar, Christopher P. Nelson, Christopher Newton-Cheh, Teemu Niiranen, Ilja M. Nolte, Teresa Nutile, Albertine J. Oldehinkel, Ben A. Oostra, Paul F. O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Arno Palotie, Alison Pattie, Brenda W. J. H. Penninx, Markus Perola, Peter J. Munson, Annette Peters, Ozren Polasek, Peter P. Pramstaller, Nguyen Quang Tri, Olli T. Raitakari, Meixia Ren, Rainer Rettig, Kenneth Rice, Paul M. Ridker, Janina S. Reid, Harriette Riese, Samuli Ripatti, Antonietta Robino, Lynda M. Rose, Jerome I. Rotter, Igor Rudan, Daniella Ruggiero, Yasaman Saba, Cinzia F. Sala, Veikko Salomaa, Nilesh J. Samani, Antti-Pekka Sarin, Rheinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V. Smith, Harold Schneider, Siim Sober, Rossella Sorice, John M. Starr, David J. Stott, David P. Strachan, Rona J. Strawbridge, Johan Sundstrom, Morris A. Swertz, Kent D. Taylor, Alexander Teumer, Martin D. Tobin, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, Andre G. Uitterlinden, Ahmad Vaez, Peter J. van der Most, Cornelia M. van Duijn, Anne-Claire Vergnaud, Germaine C. Verwoert, Veronique Vitart, Uwe Volker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H. Wild, Gonneke Willemsen, James F. Wilson, Alan F. Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R. Attia, Adam S. Butterworth, Daniel I. Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna M. M. Howson, Markku Laakso, Edward G. Lakatta, Claudia Langenberg, Ollie Melander, Dennis O. Mook-Kanamori, Patricia B. Munroe, Colin N. A. Palmer, Lorenz Risch, Robert A. Scott, Rodney J. Scott, Peter Sever, Timothy D. Spector, Pim van der Harst, Nicholas J. Wareham, Eleftheria Zeggini, Morris J. Brown, Andres Metspalu, Adriana M. Hung, Christopher O'Donnell, Todd L. Edwards, Bruce M. Psaty, Ioanna Tzoulaki, Michael R. Barnes, Louise V. Wain, Paul Elliott, Mark J. Caulfield,

    Journal Article - 2018-09-15

Cid:524942

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