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Publication

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Publication type

Journal Article

Authors

  1. Amy R. Bentley
  2. Yun J. Sung
  3. Michael R. Brown
  4. Thomas W. Winkler
  5. Aldi T. Kraja
  6. Ioanna Ntalla
  7. Karen Schwander
  8. Daniel I. Chasman
  9. Elise Lim
  10. Xuan Deng
  11. Xiuqing Guo
  12. Jingmin Liu
  13. Yingchang Lu
  14. Ching-Yu Cheng
  15. Xueling Sim
  16. Dina Vojinovic
  17. Jennifer E. Huffman
  18. Solomon K. Musani
  19. Changwei Li
  20. Mary F. Feitosa
  21. Melissa A. Richard
  22. Raymond Noordam
  23. Jenna Baker
  24. Guanjie Chen
  25. Hugues Aschard
  26. Traci M. Bartz
  27. Jingzhong Ding
  28. Rajkumar Dorajoo
  29. Alisa K. Manning
  30. Tuomo Rankinen
  31. Albert V. Smith
  32. Salman M. Tajuddin
  33. Wei Zhao
  34. Mariaelisa Graff
  35. Maris Alver
  36. Mathilde Boissel
  37. Jin Fang Chai
  38. Xu Chen
  39. Jasmin Divers
  40. Evangelos Evangelou
  41. Chuan Gao
  42. Anuj Goel
  43. Yanick Hagemeijer
  44. Sarah E. Harris
  45. Fernando P. Hartwig
  46. Meian He
  47. Andrea R.V.R. Horimoto
  48. Fang-Chi Hsu
  49. Yi-Jen Hung
  50. Anne U. Jackson
  51. Anuradhani Kasturiratne
  52. Pirjo Komulainen
  53. Brigitte Kuhnel
  54. Karin Leander
  55. Keng-Hung Lin
  56. Jian’an Luan
  57. Leo-Pekka Lyytikäinen
  58. Nana Matoba
  59. Ilja M. Nolte
  60. Maik Pietzner
  61. Bram Prins
  62. Muhammad Riaz
  63. Antonietta Robino
  64. M. Abdullah Said
  65. Nicole Schupf
  66. Robert A. Scott
  67. Tamar Sofer
  68. Alena Stančáková
  69. Fumihiko Takeuchi
  70. Bamidele O. Tayo
  71. Peter J. van der Most
  72. Tibor V. Varga
  73. Tzung-Dau Wang
  74. Yajuan Wang
  75. Erin B. Ware
  76. Wanqing Wen
  77. Yong-Bing Xiang
  78. Lisa R. Yanek
  79. Weihua Zhang
  80. Jing Hua Zhao
  81. Adebowale Adeyemo
  82. Saima Afaq
  83. Najaf Amin
  84. Marzyeh Amini
  85. Dan E. Arking
  86. Zorayr Arzumanyan
  87. Tin Aung
  88. Christie Ballantyne
  89. R. Graham Barr
  90. Lawrence F. Bielak
  91. Eric Boerwinkle
  92. Erwin P. Bottinger
  93. Ulrich Broeckel
  94. Morris Brown
  95. Brian E. Cade
  96. Archie Campbell
  97. Mickaël Canouil
  98. Sabanayagam Charumathi
  99. Yii-Der Ida Chen
  100. Kaare Christensen
  101. Maria Pina Concas
  102. John M. Connell
  103. Lisa de las Fuentes
  104. H. Janaka de Silva
  105. Paul S. de Vries
  106. Ayo Doumatey
  107. Qing Duan
  108. Charles B. Eaton
  109. Ruben N. Eppinga
  110. Jessica D. Faul
  111. James S. Floyd
  112. Nita G. Forouhi
  113. Terrence Forrester
  114. Yechiel Friedlander
  115. Ilaria Gandin
  116. He Gao
  117. Mohsen Ghanbari
  118. Sina A. Gharib
  119. Bruna Gigante
  120. Franco Giulianini
  121. Hans J. Grabe
  122. C. Charles Gu
  123. Tamara B. Harris
  124. Sami Heikkinen
  125. Chew-Kiat Heng
  126. Makoto Hirata
  127. James E. Hixson
  128. M. Arfan Ikram
  129. Yucheng Jia
  130. Roby Joehanes
  131. Craig Johnson
  132. Jost Bruno Jonas
  133. Anne E. Justice
  134. Tomohiro Katsuya
  135. Chiea Chuen Khor
  136. Tuomas O. Kilpeläinen
  137. Woon-Puay Koh
  138. Ivana Kolcic
  139. Charles Kooperberg
  140. Jose E. Krieger
  141. Stephen B. Kritchevsky
  142. Michiaki Kubo
  143. Johanna Kuusisto
  144. Timo A. Lakka
  145. Carl D. Langefeld
  146. Claudia Langenberg
  147. Lenore J. Launer
  148. Benjamin Lehne
  149. Cora E. Lewis
  150. Yize Li
  151. Jingjing Liang
  152. Shiow Lin
  153. Ching-Ti Liu
  154. Jianjun Liu
  155. Kiang Liu
  156. Marie Loh
  157. Kurt K. Lohman
  158. Tin Louie
  159. Anna Luzzi
  160. Reedik Mägi
  161. Anubha Mahajan
  162. Ani W. Manichaikul
  163. Colin A. McKenzie
  164. Thomas Meitinger
  165. Andres Metspalu
  166. Yuri Milaneschi
  167. Lili Milani
  168. Karen L. Mohlke
  169. Yukihide Momozawa
  170. Andrew P. Morris
  171. Alison D. Murray
  172. Mike A. Nalls
  173. Matthias Nauck
  174. Christopher P. Nelson
  175. Kari E. North
  176. Jeffrey R. O’Connell
  177. Nicholette D. Palmer
  178. George J. Papanicolau
  179. Nancy L. Pedersen
  180. Annette Peters
  181. Patricia A. Peyser
  182. Ozren Polasek
  183. Neil Poulter
  184. Olli T. Raitakari
  185. Alex P. Reiner
  186. Frida Renström
  187. Treva K. Rice
  188. Stephen S. Rich
  189. Jennifer G. Robinson
  190. Lynda M. Rose
  191. Frits R. Rosendaal
  192. Igor Rudan
  193. Carsten O. Schmidt
  194. Pamela J. Schreiner
  195. William R. Scott
  196. Peter Sever
  197. Yuan Shi
  198. Stephen Sidney
  199. Mario Sims
  200. Jennifer A. Smith
  201. Harold Snieder
  202. John M. Starr
  203. Konstantin Strauch
  204. Heather M. Stringham
  205. Nicholas Y.Q. Tan
  206. Hua Tang
  207. Kent D. Taylor
  208. Yik Ying Teo
  209. Yih Chung Tham
  210. Henning Tiemeier
  211. Stephen T. Turner
  212. André G. Uitterlinden
  213. Diana van Heemst
  214. Melanie Waldenberger
  215. Heming Wang
  216. Lan Wang
  217. Lihua Wang
  218. Wen Bin Wei
  219. Christine A. Williams
  220. Gregory Wilson
  221. Mary K. Wojczynski
  222. Jie Yao
  223. Kristin Young
  224. Caizheng Yu
  225. Jian-Min Yuan
  226. Jie Zhou
  227. Alan B. Zonderman
  228. Diane M. Becker
  229. Michael Boehnke
  230. Donald W. Bowden
  231. John C. Chambers
  232. Richard S. Cooper
  233. Ulf de Faire
  234. Ian J. Deary
  235. Paul Elliott
  236. Tõnu Esko
  237. Martin Farrall
  238. Paul W. Franks
  239. Barry I. Freedman
  240. Philippe Froguel
  241. Paolo Gasparini
  242. Christian Gieger
  243. Bernardo L. Horta
  244. Jyh-Ming Jimmy Juang
  245. Yoichiro Kamatani
  246. Candace M. Kammerer
  247. Norihiro Kato
  248. Jaspal S. Kooner
  249. Markku Laakso
  250. Cathy C. Laurie
  251. I. Te Lee
  252. Terho Lehtimäki
  253. Patrik K.E. Magnusson
  254. Albertine J. Oldehinkel
  255. Brenda W.J.H. Penninx
  256. Alexandre C. Pereira
  257. Rainer Rauramaa
  258. Susan Redline
  259. Nilesh J. Samani
  260. James Scott
  261. Xiao-Ou Shu
  262. Pim van der Harst
  263. Lynne E. Wagenknecht
  264. Jun-Sing Wang
  265. Ya Xing Wang
  266. Nicholas J. Wareham
  267. Hugh Watkins
  268. David R. Weir
  269. Ananda R. Wickremasinghe
  270. Tangchun Wu
  271. Eleftheria Zeggini
  272. Wei Zheng
  273. Claude Bouchard
  274. Michele K. Evans
  275. Vilmundur Gudnason
  276. Sharon L.R. Kardia
  277. Yongmei Liu
  278. Bruce M. Psaty
  279. Paul M. Ridker
  280. Rob M. van Dam
  281. Dennis O. Mook-Kanamori
  282. Myriam Fornage
  283. Michael A. Province
  284. Tanika N. Kelly
  285. Ervin R. Fox
  286. Caroline Hayward
  287. Cornelia M. van Duijn
  288. E. Shyong Tai
  289. Tien Yin Wong
  290. Ruth J.F. Loos
  291. Nora Franceschini
  292. Jerome I. Rotter
  293. Xiaofeng Zhu
  294. Laura J. Bierut
  295. W. James Gauderman
  296. Kenneth Rice
  297. Patricia B. Munroe
  298. Alanna C. Morrison
  299. Dabeeru C. Rao
  300. Charles N. Rotimi
  301. L. Adrienne Cupples

Publication date

April 15, 2019

Summary

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Volume and page numbers

Volume: 51 , p.636 -648

DOI

https://doi.org/10.1038/s41588-019-0378-y

ISSN

10614036

Subjects

Notes

University of Essex, Albert Sloman Library *University of Essex registered users - Campus access*

Cid:525642

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