Grip strength modifies the association between estimated glomerular filtration rate and all-cause mortality

Publication type

Journal Article

Published in

Nephrology Dialysis Transplantation

Authors

Per-Ola Sundin, Ruzan Udumyan, Katja Fall and Scott Montgomery

Publication date

Summary

Chronic kidney disease (CKD) with reduced glomerular filtration rate (GFR) represents a high-magnitude increased risk for cardiovascular disease (CVD) and all-cause mortality (ACM). The main non-GFR determinant of the endogenous filtration marker creatinine is its production rate in muscle. Stratification of GFR by a marker of muscle function (grip strength) associated with muscle mass may remove heterogeneity, providing a more accurate marker of mortality risk.
This study evaluates whether grip strength identifies ACM risk associated with estimated GFR (eGFR) from serum creatinine in a subsample of the UK Household Longitudinal Survey (UKHLS).

Volume and page numbers

34, 1799-1801

DOI

https://doi.org/10.1093/ndt/gfz140

ISSN

16

Subjects

Medicine, Health and Biology

Notes

Open Access; © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.