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Search found 33 items

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill

Older PeopleLife Course AnalysisBiologyGenetics


Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig

HealthBiologyGenetics


Associations of autozygosity with a broad range of human phenotypes

David W. Clark, Yukinori Okada, Kristjan H.S. Moore, Dan Mason, Nicola Pirastu, Ilaria Gandin, Hannele Mattsson, Catriona L.K. Barnes, Kuang Lin, Jing Hua Zhao

Childbearing: FertilityBiologyGenetics


The transferability of lipid loci across African, Asian and European cohorts

Karoline Kuchenbaecker, Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Anders Eriksson, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis

MedicineDemographyEthnic GroupsHealthBiologyGenetics


The association between self-rated health and underlying biomarker levels is modified by age, gender, and household income: evidence from Understanding Society – the UK Household Longitudinal Study

M. Pia Chaparro, Amanda Hughes, Meena Kumari, Michaela Benzeval

Social GroupsDemographyIncome DynamicsHealthBiology


Are flexible work arrangements associated with lower levels of chronic stress-related biomarkers? A study of 6025 employees in the UK Household Longitudinal Study

Tarani Chandola, Cara L. Booker, Meena Kumari, Michaela Benzeval

Sociology Of LabourLabour MarketWell BeingHealthCaregivingBiology


Early-life inequalities and biological ageing: a multisystem Biological Health Score approach in Understanding Society

Maryam Karimi, Raphaële Castagné, Cyrille Delpierre, Gaëlle Albertus, Eloïse Berger, Paolo Vineis, Meena Kumari, Michelle Kelly-Irving, Marc Chadeau-Hyam

HealthLife Course AnalysisSocial StratificationBiology


Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

Georgina Mansell, Tyler J. Gorrie-Stone, Yanchun Bao, Meena Kumari, Leonard S. Schalkwyk, Jonathan Mill, Eilis Hannon

Statistical AnalysisBiologyGenetics


Assessing the robustness of sisVIVE in a Mendelian randomization study to estimate the causal effect of body mass index on income using multiple SNPs from Understanding Society

Yanchun Bao, Paul Clarke, Melissa Smart, Meena Kumari

Income DynamicsBiologyGenetics


Assessing potential shared genetic aetiology between body mass index and sleep duration in 142,209 individuals

Victoria Garfield, Ghazaleh Fatemifar, Caroline Dale, Melissa Smart, Yanchun Bao, Clare H. Llewellyn, Andrew Steptoe, Delilah Zabaneh, Meena Kumari

Science And TechnologyHealthBiologyGenetics


Bigmelon: tools for analysing large DNA methylation datasets

Tyler J. Gorrie-Stone, Melissa Smart, Ayden Saffari, Karim Malki, Eilis Hannon, Joe Burrage, Jonathan Mill, Meena Kumari, Leonard C. Schalkwyk

Statistical AnalysisComputingGenetics


The authors reply

Amanda Hughes, Yanchun Bao, Melissa Smart, Tyler Gorrie-Stone, Eilis Hannon, Jonathan Mill, Joe Burrage, Leo Schalkwyk, Meena Kumari

HealthLife Course AnalysisSocial StratificationBiologyGenetics


The transferability of lipid-associated loci across African, Asian and European cohorts

Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis, Maria Karaleftheri, Janet Seeley

MedicineDemographyEthnic GroupsHealthBiologyGenetics


Testosterone, risk, and socioeconomic position in British men: exploring causal directionality

Amanda Hughes, Meena Kumari

Social StratificationBiologyGenetics


Multivariate genome-wide analyses of the well-being spectrum

Bart M. L. Baselmans, Rick Jansen, Hill F. Ip, Jenny van Dongen, Abdel Abdellaoui, Margot P. van de Weijer, Yanchun Bao, Melissa Smart, Meena Kumari, Gonneke Willemsen

PsychologyMedicineScience And TechnologyWell BeingHealthBiologyGenetics


Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S. Fleur W. Meddens, Robbee Wedow, Mark Alan Fontana, Maël Lebreton, Stephen P. Tino, Abdel Abdellaoui, Anke R. Hammerschlag

Drug/Alcohol AbuseHealthSocial BehaviourBiologyGenetics


Socioeconomic position and DNA methylation age acceleration across the lifecourse

Amanda Hughes, Melissa Smart, Tyler Gorrie-Stone, Eilis Hannon, Jonathan Mill, Yanchun Bao, Joe Burrage, Leo Schalkwyk, Meena Kumari

HealthLife Course AnalysisSocial StratificationBiologyGenetics


Leveraging DNA-methylation quantitative-trait loci to characterize the relationship between methylomic variation, gene expression, and complex traits

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa Smart, Joe Burrage, Amanda Hughes, Yanchun Bao, Meena Kumari, Leonard C. Schalkwyk, Jonathan Mill

Science And TechnologyResearchHealthBiologyGenetics


Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér

EducationBiologyGenetics


Age modification of the relationship between C-reactive protein and fatigue: findings from Understanding Society (UKHLS)

Amanda Hughes, Meena Kumari

MedicineHealthBiology


Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure

Madeleine J. Murtagh, Mwenza T. Blell, Olly W. Butters, Lorraine Cowley, Edward S. Dove, Alissa Goodman, Rebecca L. Griggs, Alison Hall, Nina Hallowell, Meena Kumari

MedicineScience And TechnologyResearchSurveysBiologyGenetics


Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa Smart, Joe Burrage, Amanda Hughes, Yanchun Bao, Meena Kumari, Leonard C. Schalkwyk, Jonathan Mill

Science And TechnologyResearchHealthBiologyGenetics


Gene-environment interactions between education and body mass: evidence from the UK and Finland

Vikesh Amin, Petri Böckerman, Jutta Viinikainen, Melissa Smart, Yanchun Bao, Meena Kumari, Niina Pitkänen, Terho Lehtimäki, Olli Raitakari, Jaakko Pehkonen

EducationHealthBiologyGenetics


Associations of C-reactive protein and psychological distress are modified by antidepressants, supporting an inflammatory depression subtype: findings from UKHLS

Amanda Hughes, Meena Kumari

PsychologyMedicineWell BeingHealthBiology


Vitamin D and cognitive function: a Mendelian randomisation study

Jane Maddock, Ang Zhou, Alana Cavadino, Elżbieta Kuźma, Yanchun Bao, Melissa Smart, Kai-Uwe Saum, Ben Schöttker, Jorgen Engmann, Marie Kjærgaard

Older PeoplePsychologyScience And TechnologyHealthLife Course AnalysisGenetics