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Search found 18 items

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter

HealthBiologyGenetics


Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff

MedicineScience And TechnologyHealthBiologyGenetics


Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Ayush Giri, Jacklyn N. Hellwege, Jacob M. Keaton, Jihwan Park, Chengxiang Qiu, Helen R. Warren, Eric S. Torstenson, Csaba P. Kovesdy, Yan V. Sun, Otis D. Wilson

Ethnic GroupsHealthBiologyGenetics


Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, Ioanna Ntalla, Karen Schwander, Daniel I. Chasman, Elise Lim, Xuan Deng

Drug/Alcohol AbuseDemographyHealthBiology


New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine, Anna L. Guyatt, A. Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl A. Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung Song, Phuwanat Sakornsakolpat

HealthBiologyGenetics


Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

A. Mesut Erzurumluoglu, MengZhen Liu, Victoria E. Jackson, Daniel R. Barnes, Gauri Datta, Carl A. Melbourne, Robin Young, Chiara Batini, Praveen Surendran, Tao Jiang

HealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff

MedicineScience And TechnologyHealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


Novel blood pressure locus and gene discovery using Genome-Wide Association Study and expression data sets from blood and the kidney

Louise Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose

Science And TechnologyHealthBiologyGenetics


Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity

Audrey E. Hendricks, Elena G. Bochukova, Gaëlle Marenne, Julia M. Keogh, Neli Atanassova, Rebecca Bounds, Eleanor Wheeler, Vanisha Mistry, Elana Henning, Antje Körner

Science And TechnologyYoung PeopleHealthBiologyGenetics


Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca A. Lotta, Pawan Gulati, Felix R. Day, Felicity Payne, Halit Ongen, Martijn van de Bunt, Kyle J. Gaulton, John D. Eicher, Stephen J. Sharp, Jian'an Luan

MedicineScience And TechnologyHealthBiologyGenetics


Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits

Ioanna Tachmazidou, Dániel Süveges, Josine L. Min, Graham R. S. Ritchie, Julia Steinberg, Klaudia Walter, Valentina Iotchkova, Jeremy Schwartzentruber, Jie Huang, Yasin Memari

Science And TechnologyHealthBiologyGenetics


Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations

Bram P. Prins, Karoline B. Kuchenbaecker, Yanchun Bao, Melissa Smart, Delilah Zabaneh, Ghazaleh Fatemifar, Jian’an Luan, Nick J. Wareham, Robert A. Scott, John R.B. Perry

Science And TechnologyHealthBiologyGenetics


Corrigendum: integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca A. Lotta, Pawan Gulati, Felix R. Day, Felicity Payne, Halit Ongen, Martijn van de Bunt, Kyle J. Gaulton, John D. Eicher, Stephen J. Sharp, Jian'an Luan

MedicineScience And TechnologyHealthBiologyGenetics


Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

Louise Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose

Science And TechnologyHealthBiologyGenetics


Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Helen R. Warren, Evangelos Evangelou, Claudia P. Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P. Cook

MedicineScience And TechnologyHealthBiologyGenetics


Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, Alisa K. Manning, Niels Grarup, Xueling Sim, Daniel R. Barnes, Kate Witkowska

MedicineScience And TechnologyHealthBiologyGenetics