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Search found 23 items

Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use

David M. Brazel, Yu Jiang, Jordan M. Hughey, Valérie Turcot, Xiaowei Zhan, Jian Gong, Chiara Batini, J. Dylan Weissenkampen, MengZhen Liu, Daniel R. Barnes

Drug/Alcohol AbuseMedicineScience And TechnologyPsychiatryHealthBiologyGenetics


Socioeconomic position and DNA methylation age acceleration across the lifecourse

Amanda Hughes, Melissa Smart, Tyler Gorrie-Stone, Eilis Hannon, Jonathan Mill, Yanchun Bao, Joe Burrage, Leo Schalkwyk, Meena Kumari

HealthLife Course AnalysisSocial StratificationBiologyGenetics


Leveraging DNA-methylation quantitative-trait loci to characterize the relationship between methylomic variation, gene expression, and complex traits

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa Smart, Joe Burrage, Amanda Hughes, Yanchun Bao, Meena Kumari, Leonard C. Schalkwyk, Jonathan Mill

Science And TechnologyResearchHealthBiologyGenetics


Parametric models for biomarkers based on flexible size distributions

Apostolos Davillas, Andrew M. Jones

Statistical MathematicsHealthSurveysBiology


Intergenerational social mobility and allostatic load in Great Britain

Patrick Präg, Lindsay Richards

Well BeingHealthSocial StratificationSocial MobilityBiology


Common genetic variants contribute to risk of rare severe neurodevelopmental disorders

Mari E. K. Niemi, Hilary C. Martin, Daniel L. Rice, Giuseppe Gallone, Scott Gordon, Martin Kelemen, Kerrie McAloney, Jeremy McRae, Elizabeth J. Radford, Sui Yu

MedicineChild DevelopmentHealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


A single complex Agpat2 allele in a patient with partial lipodystrophy

Marjoleine F. Broekema, Maarten P.G. Massink, Joep De Ligt, Edwin C.A. Stigter, Houshang Monajemi, Jeroen De Ridder, Boudewijn M.T. Burgering, Gijs W. van Haaften, Eric Kalkhoven

MedicineHealthBiologyGenetics


Stressed out? An investigation of whether allostatic load mediates associations between neighbourhood deprivation and health

Lucy Prior, David Manley, Kelvyn Jones

Area EffectsGeographyPovertyWell BeingHealthBiology


Informal caregiving and markers of adiposity in the UK Household Longitudinal Study

Rebecca E. Lacey, Anne McMunn, Elizabeth Webb

DemographyLabour MarketHealthCaregivingBiology


Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér

EducationBiologyGenetics


Age modification of the relationship between C-reactive protein and fatigue: findings from Understanding Society (UKHLS)

Amanda Hughes, Meena Kumari

MedicineHealthBiology


Neighborhood deprivation and biomarkers of health in Britain: the mediating role of the physical environment

M. Pia Chaparro, Michaela Benzeval, Elizabeth Richardson, Richard Mitchell

Area EffectsGeographyHealthBiology


Social patterning in grip strength and in its association with age; a cross sectional analysis using the UK Household Longitudinal Study (UKHLS)

Caroline Carney, Michaela Benzeval

MedicineHealthLife Course AnalysisSocial StratificationBiology


Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

Konstantinos Hatzikotoulas, Andreas Roposch, Karan M. Shah, Matthew J. Clark, Selina Bratherton, Vasanti Limbani, Julia Steinberg, Eleni Zengini, Kaltuun Warsame, Madhushika Ratnayake

MedicineHealthBiologyGenetics


Does general intelligence moderate the association between inflammation and psychological distress?

Emily Midouhas, Eirini Flouri, Efstathios Papachristou, Theodora Kokosi

PsychologyWell BeingHealthBiology


Common genetic variants contribute to risk of rare severe neurodevelopmental disorders

Mari E. K. Niemi, Hilary C. Martin, Daniel L. Rice, Giuseppe Gallone, Scott Gordon, Martin Kelemen, Kerrie McAloney, Jeremy McRae, Elizabeth J. Radford, Sui Yu

MedicineChild DevelopmentHealthBiologyGenetics


Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure

Madeleine J. Murtagh, Mwenza T. Blell, Olly W. Butters, Lorraine Cowley, Edward S. Dove, Alissa Goodman, Rebecca L. Griggs, Alison Hall, Nina Hallowell, Meena Kumari

MedicineScience And TechnologyResearchSurveysBiologyGenetics


Testosterone and tendency to engage in self-employment

Nicos Nicolaou, Pankaj C. Patel, Marcus T. Wolfe

Management: BusinessLabour MarketOrganizations And FirmsSocial BehaviourBiology


Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa Smart, Joe Burrage, Amanda Hughes, Yanchun Bao, Meena Kumari, Leonard C. Schalkwyk, Jonathan Mill

Science And TechnologyResearchHealthBiologyGenetics


Informal caregiving and metabolic markers in the UK Household Longitudinal Study

Rebecca E. Lacey, Anne McMunn, Elizabeth A. Webb

HealthCaregivingBiology


Re-employment, job quality, health and allostatic load biomarkers: prospective evidence from the UK Household Longitudinal Study

Tarani Chandola, Nan Zhang

Labour MarketUnemploymentWell BeingHealthBiology


Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff

MedicineScience And TechnologyHealthBiologyGenetics