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Search found 51 items

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Ayush Giri, Jacklyn N. Hellwege, Jacob M. Keaton, Jihwan Park, Chengxiang Qiu

Ethnic GroupsHealthBiologyGenetics


Bigmelon: tools for analysing large DNA methylation datasets

Tyler J. Gorrie-Stone, Melissa Smart, Ayden Saffari, Karim Malki, Eilis Hannon

Statistical AnalysisComputingGenetics


New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine, Anna L. Guyatt, A. Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs

HealthBiologyGenetics


The authors reply

Amanda Hughes, Yanchun Bao, Melissa Smart, Tyler Gorrie-Stone, Eilis Hannon

HealthLife Course AnalysisSocial StratificationBiologyGenetics


Genetic architecture of human thinness compared to severe obesity

Fernando Riveros-McKay, Vanisha Mistry, Rebecca Bounds, Audrey Hendricks, Julia M. Keogh

HealthBiologyGenetics


Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland

HealthGenetics


The transferability of lipid-associated loci across African, Asian and European cohorts

Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Deepti Gurdasani

MedicineDemographyEthnic GroupsHealthBiologyGenetics


Multivariate genome-wide analyses of the well-being spectrum

Bart M. L. Baselmans, Rick Jansen, Hill F. Ip, Jenny van Dongen, Abdel Abdellaoui

PsychologyMedicineScience And TechnologyWell BeingHealthBiologyGenetics


Testosterone, risk, and socioeconomic position in British men: exploring causal directionality

Amanda Hughes, Meena Kumari

Social StratificationBiologyGenetics


Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S. Fleur W. Meddens, Robbee Wedow

Drug/Alcohol AbuseSocial BehaviourBiologyGenetics


Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

A. Mesut Erzurumluoglu, MengZhen Liu, Victoria E. Jackson, Daniel R. Barnes, Gauri Datta

HealthBiologyGenetics


Assessing the robustness of sisVIVE in a Mendelian randomization study to estimate the causal effect of body mass index on income using multiple SNPs from Understanding Society

Yanchun Bao, Paul Clarke, Melissa Smart, Meena Kumari

Income DynamicsBiologyGenetics


Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use

David M. Brazel, Yu Jiang, Jordan M. Hughey, Valérie Turcot, Xiaowei Zhan

Drug/Alcohol AbuseMedicineScience And TechnologyPsychiatryHealthBiologyGenetics


Assessing potential shared genetic aetiology between body mass index and sleep duration in 142,209 individuals

Victoria Garfield, Ghazaleh Fatemifar, Caroline Dale, Melissa Smart, Yanchun Bao

Science And TechnologyHealthBiologyGenetics


Socioeconomic position and DNA methylation age acceleration across the lifecourse

Amanda Hughes, Melissa Smart, Tyler Gorrie-Stone, Eilis Hannon, Jonathan Mill

HealthLife Course AnalysisSocial StratificationBiologyGenetics


Leveraging DNA-methylation quantitative-trait loci to characterize the relationship between methylomic variation, gene expression, and complex traits

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa Smart, Joe Burrage, Amanda Hughes

Science And TechnologyResearchHealthBiologyGenetics


Common genetic variants contribute to risk of rare severe neurodevelopmental disorders

Mari E. K. Niemi, Hilary C. Martin, Daniel L. Rice, Giuseppe Gallone, Scott Gordon

MedicineChild DevelopmentHealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki

MedicineScience And TechnologyHealthBiologyGenetics


A single complex Agpat2 allele in a patient with partial lipodystrophy

Marjoleine F. Broekema, Maarten P.G. Massink, Joep De Ligt, Edwin C.A. Stigter, Houshang Monajemi

MedicineHealthBiologyGenetics


Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian

EducationBiologyGenetics


Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 3; referees: 2 approved]

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove

MedicineScience And TechnologyHealthGenetics


Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

Konstantinos Hatzikotoulas, Andreas Roposch, Karan M. Shah, Matthew J. Clark, Selina Bratherton

MedicineHealthBiologyGenetics


Common genetic variants contribute to risk of rare severe neurodevelopmental disorders

Mari E. K. Niemi, Hilary C. Martin, Daniel L. Rice, Giuseppe Gallone, Scott Gordon

MedicineChild DevelopmentHealthBiologyGenetics


Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure

Madeleine J. Murtagh, Mwenza T. Blell, Olly W. Butters, Lorraine Cowley, Edward S. Dove

MedicineScience And TechnologyResearchSurveysBiologyGenetics


Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits

Eilis Hannon, Tyler J. Gorrie-Stone, Melissa Smart, Joe Burrage, Amanda Hughes

Science And TechnologyResearchHealthBiologyGenetics