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Search found 14 items

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F. Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim

Drug/Alcohol AbuseHealthBiologyGenetics


New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine, Anna L. Guyatt, A. Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl A. Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung Song, Phuwanat Sakornsakolpat

HealthBiologyGenetics


Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

A. Mesut Erzurumluoglu, MengZhen Liu, Victoria E. Jackson, Daniel R. Barnes, Gauri Datta, Carl A. Melbourne, Robin Young, Chiara Batini, Praveen Surendran, Tao Jiang

HealthBiologyGenetics


Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use

David M. Brazel, Yu Jiang, Jordan M. Hughey, Valérie Turcot, Xiaowei Zhan, Jian Gong, Chiara Batini, J. Dylan Weissenkampen, MengZhen Liu, Daniel R. Barnes

Drug/Alcohol AbuseMedicineScience And TechnologyPsychiatryHealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 3; referees: 2 approved]

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser

MedicineScience And TechnologyHealthGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


Novel blood pressure locus and gene discovery using Genome-Wide Association Study and expression data sets from blood and the kidney

Louise Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose

Science And TechnologyHealthBiologyGenetics


Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

H. Aschard, Martin D. Tobin, D. B. Hancock, D. Skurnik, A. Sood, A. James, A. V. Smith, A. W. Manichaikul, A. Campbell, B. P. Prins

Drug/Alcohol AbuseMedicineScience And TechnologyHealthBiologyGenetics


Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits

Ioanna Tachmazidou, Dániel Süveges, Josine L. Min, Graham R. S. Ritchie, Julia Steinberg, Klaudia Walter, Valentina Iotchkova, Jeremy Schwartzentruber, Jie Huang, Yasin Memari

Science And TechnologyHealthBiologyGenetics


Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

Louise Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose

Science And TechnologyHealthBiologyGenetics


Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Louise V. Wain, Nick Shrine, María Soler Artigas, A. Mesut Erzurumluoglu, Boris Noyvert, L. Bossini-Castillo, M. Obeidat, A. P. Henry, M. A . Portelli, R. J. Hall

MedicineScience And TechnologyHealthBiologyGenetics


Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Helen R. Warren, Evangelos Evangelou, Claudia P. Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P. Cook

MedicineScience And TechnologyHealthBiologyGenetics


Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P. Cook, Alisa K. Manning, Niels Grarup, Xueling Sim, Daniel R. Barnes, Kate Witkowska

MedicineScience And TechnologyHealthBiologyGenetics