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Search found 78 items

Speed of aging during life span measured by new tool

Daniel W.W. Belsky, Avshalom Caspi, Louise Arseneault, Andrea Baccarelli, David L. Corcoran, Xu Gao, Eiliss Hannon, Hona Lee Harrington, Line J.H. Rasmussen, Renate Houts

HealthLife Course AnalysisBiologyGenetics


New tool may offer a novel approach to prevent multiple chronic diseases

Daniel W.W. Belsky, Avshalom Caspi, Louise Arseneault, Andrea Baccarelli, David L. Corcoran, Xu Gao, Eiliss Hannon, Hona Lee Harrington, Line J.H. Rasmussen, Renate Houts

HealthLife Course AnalysisBiologyGenetics


Epidemiologists develop new tool for measuring the pace of aging across the life course

Daniel W.W. Belsky, Avshalom Caspi, Louise Arseneault, Andrea Baccarelli, David L. Corcoran, Xu Gao, Eiliss Hannon, Hona Lee Harrington, Line J.H. Rasmussen, Renate Houts

HealthLife Course AnalysisBiologyGenetics


Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

Daniel W.W. Belsky, Avshalom Caspi, Louise Arseneault, Andrea Baccarelli, David L. Corcoran, Xu Gao, Eiliss Hannon, Hona Lee Harrington, Line J.H. Rasmussen, Renate Houts

HealthLife Course AnalysisBiologyGenetics


Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill

Older PeopleLife Course AnalysisBiologyGenetics


Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig

HealthBiologyGenetics


P06 Genetics of juvenile idiopathic arthritis: the identification of a novel risk locus and clinical subgroup analysis -conference paper abstract-

John Bowes, Annie Yarwood, Samantha Smith, Damian Tarasek, Wendy Thomson

MedicineHealthBiologyGenetics


Associations of autozygosity with a broad range of human phenotypes

David W. Clark, Yukinori Okada, Kristjan H.S. Moore, Dan Mason, Nicola Pirastu, Ilaria Gandin, Hannele Mattsson, Catriona L.K. Barnes, Kuang Lin, Jing Hua Zhao

Childbearing: FertilityBiologyGenetics


The transferability of lipid loci across African, Asian and European cohorts

Karoline Kuchenbaecker, Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Anders Eriksson, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis

MedicineDemographyEthnic GroupsHealthBiologyGenetics


Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff

MedicineScience And TechnologyHealthBiologyGenetics


Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Ayush Giri, Jacklyn N. Hellwege, Jacob M. Keaton, Jihwan Park, Chengxiang Qiu, Helen R. Warren, Eric S. Torstenson, Csaba P. Kovesdy, Yan V. Sun, Otis D. Wilson

Ethnic GroupsHealthBiologyGenetics


Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array

Georgina Mansell, Tyler J. Gorrie-Stone, Yanchun Bao, Meena Kumari, Leonard S. Schalkwyk, Jonathan Mill, Eilis Hannon

Statistical AnalysisBiologyGenetics


Assessing the robustness of sisVIVE in a Mendelian randomization study to estimate the causal effect of body mass index on income using multiple SNPs from Understanding Society

Yanchun Bao, Paul Clarke, Melissa Smart, Meena Kumari

Income DynamicsBiologyGenetics


Assessing potential shared genetic aetiology between body mass index and sleep duration in 142,209 individuals

Victoria Garfield, Ghazaleh Fatemifar, Caroline Dale, Melissa Smart, Yanchun Bao, Clare H. Llewellyn, Andrew Steptoe, Delilah Zabaneh, Meena Kumari

Science And TechnologyHealthBiologyGenetics


Bigmelon: tools for analysing large DNA methylation datasets

Tyler J. Gorrie-Stone, Melissa Smart, Ayden Saffari, Karim Malki, Eilis Hannon, Joe Burrage, Jonathan Mill, Meena Kumari, Leonard C. Schalkwyk

Statistical AnalysisComputingGenetics


Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F. Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim

Drug/Alcohol AbuseHealthBiologyGenetics


The evolutionary dynamics and fitness landscape of clonal haematopoiesis

Caroline J. Watson, Alana Papula, Yeuk P.G. Poon, Wing H. Wong, Andrew L. Young, Todd E. Druley, Daniel S. Fisher, Jamie R. Blundell

Older PeopleHealthLife Course AnalysisBiologyGenetics


New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine, Anna L. Guyatt, A. Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl A. Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung Song, Phuwanat Sakornsakolpat

HealthBiologyGenetics


The authors reply

Amanda Hughes, Yanchun Bao, Melissa Smart, Tyler Gorrie-Stone, Eilis Hannon, Jonathan Mill, Joe Burrage, Leo Schalkwyk, Meena Kumari

HealthLife Course AnalysisSocial StratificationBiologyGenetics


Genetic architecture of human thinness compared to severe obesity

Fernando Riveros-McKay, Vanisha Mistry, Rebecca Bounds, Audrey Hendricks, Julia M. Keogh, Hannah Thomas, Elana Henning, Laura J. Corbin, Stephen O’Rahilly, Eleftheria Zeggini

HealthBiologyGenetics


Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg

HealthGenetics


The transferability of lipid-associated loci across African, Asian and European cohorts

Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis, Maria Karaleftheri, Janet Seeley

MedicineDemographyEthnic GroupsHealthBiologyGenetics


Testosterone, risk, and socioeconomic position in British men: exploring causal directionality

Amanda Hughes, Meena Kumari

Social StratificationBiologyGenetics


Multivariate genome-wide analyses of the well-being spectrum

Bart M. L. Baselmans, Rick Jansen, Hill F. Ip, Jenny van Dongen, Abdel Abdellaoui, Margot P. van de Weijer, Yanchun Bao, Melissa Smart, Meena Kumari, Gonneke Willemsen

PsychologyMedicineScience And TechnologyWell BeingHealthBiologyGenetics


Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Richard Karlsson Linnér, Pietro Biroli, Edward Kong, S. Fleur W. Meddens, Robbee Wedow, Mark Alan Fontana, Maël Lebreton, Stephen P. Tino, Abdel Abdellaoui, Anke R. Hammerschlag

Drug/Alcohol AbuseHealthSocial BehaviourBiologyGenetics