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The transferability of lipid loci across African, Asian and European cohorts

Karoline Kuchenbaecker, Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Anders Eriksson, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis

MedicineDemographyEthnic GroupsHealthBiologyGenetics


Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff

MedicineScience And TechnologyHealthBiologyGenetics


Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Ayush Giri, Jacklyn N. Hellwege, Jacob M. Keaton, Jihwan Park, Chengxiang Qiu, Helen R. Warren, Eric S. Torstenson, Csaba P. Kovesdy, Yan V. Sun, Otis D. Wilson

Ethnic GroupsHealthBiologyGenetics


GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

Unnur Styrkarsdottir, Olafur A. Stefansson, Kristbjorg Gunnarsdottir, Gudmar Thorleifsson, Sigrun H. Lund, Lilja Stefansdottir, Kristinn Juliusson, Arna B. Agustsdottir, Florian Zink, Gisli H. Halldorsson


Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Amy R. Bentley, Yun J. Sung, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, Ioanna Ntalla, Karen Schwander, Daniel I. Chasman, Elise Lim, Xuan Deng

Drug/Alcohol AbuseDemographyHealthBiology


New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Nick Shrine, Anna L. Guyatt, A. Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl A. Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung Song, Phuwanat Sakornsakolpat

HealthBiologyGenetics


Genetic architecture of human thinness compared to severe obesity

Fernando Riveros-McKay, Vanisha Mistry, Rebecca Bounds, Audrey Hendricks, Julia M. Keogh, Hannah Thomas, Elana Henning, Laura J. Corbin, Stephen O’Rahilly, Eleftheria Zeggini

HealthBiologyGenetics


Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg

HealthGenetics


The transferability of lipid-associated loci across African, Asian and European cohorts

Nikita Telkar, Theresa Reiker, Robin G. Walters, Kuang Lin, Deepti Gurdasani, Arthur Gilly, Lorraine Southam, Emmanouil Tsafantakis, Maria Karaleftheri, Janet Seeley

MedicineDemographyEthnic GroupsHealthBiologyGenetics


Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

A. Mesut Erzurumluoglu, MengZhen Liu, Victoria E. Jackson, Daniel R. Barnes, Gauri Datta, Carl A. Melbourne, Robin Young, Chiara Batini, Praveen Surendran, Tao Jiang

HealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 3; referees: 2 approved]

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma'en Obeidat, Michael A. Province, Wei Gao, Beenish Qaiser

MedicineScience And TechnologyHealthGenetics


Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

Konstantinos Hatzikotoulas, Andreas Roposch, Karan M. Shah, Matthew J. Clark, Selina Bratherton, Vasanti Limbani, Julia Steinberg, Eleni Zengini, Kaltuun Warsame, Madhushika Ratnayake

MedicineHealthBiologyGenetics


A novel variant in GLIS3 is associated with osteoarthritis

Elisabetta Casalone, Ioanna Tachmazidou, Eleni Zengini, Konstantinos Hatzikotoulas, Sophie Hackinger, Dániel Süveges, Julia Steinberg, Nigel William Rayner, Jeremy Mark Wilkinson, Kalliope Panoutsopoulou

MedicineScience And TechnologyHealthGenetics


Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff

MedicineScience And TechnologyHealthBiologyGenetics


New blood pressure–associated loci identified in meta-analyses of 475 000 individuals

Aldi T. Kraja, James P. Cook, Helen R. Warren, Praveen Surendran, Chunyu Liu, Evangelos Evangelou, Alisa K. Manning, Niels Grarup, Fotios Drenos, Xueling Sim

MedicineScience And TechnologyHealthBiologyGenetics


Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman

MedicineScience And TechnologyHealthBiologyGenetics


A Genome-Wide Association Study of Dupuytren disease reveals 17 additional variants implicated in fibrosis

Michael Ng, Dipti Thakkar, Lorraine Southam, Paul Werker, Roel Ophoff, Kerstin Becker, Michael Nothnagel, Andre Franke, Peter Nürnberg, Ana Isabel Espirito-Santo

MedicineHealthBiologyGenetics


Novel blood pressure locus and gene discovery using Genome-Wide Association Study and expression data sets from blood and the kidney

Louise Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose

Science And TechnologyHealthBiologyGenetics


Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity

Audrey E. Hendricks, Elena G. Bochukova, Gaëlle Marenne, Julia M. Keogh, Neli Atanassova, Rebecca Bounds, Eleanor Wheeler, Vanisha Mistry, Elana Henning, Antje Körner

Science And TechnologyYoung PeopleHealthBiologyGenetics


Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits

Ioanna Tachmazidou, Dániel Süveges, Josine L. Min, Graham R. S. Ritchie, Julia Steinberg, Klaudia Walter, Valentina Iotchkova, Jeremy Schwartzentruber, Jie Huang, Yasin Memari

Science And TechnologyHealthBiologyGenetics


Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations

Bram P. Prins, Karoline B. Kuchenbaecker, Yanchun Bao, Melissa Smart, Delilah Zabaneh, Ghazaleh Fatemifar, Jian’an Luan, Nick J. Wareham, Robert A. Scott, John R.B. Perry

Science And TechnologyHealthBiologyGenetics


Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits

Lorraine Southam, Arthur Gilly, Dániel Süveges, Aliki-Eleni Farmaki, Jeremy Schwartzentruber, Ioanna Tachmazidou, Angela Matchan, Nigel W. Rayner, Emmanouil Tsafantakis, Maria Karaleftheri

MedicineScience And TechnologyHealthBiologyGenetics


Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

Louise Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, A. Mesut Erzurumluoglu, Paul O'Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose

Science And TechnologyHealthBiologyGenetics


Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Helen R. Warren, Evangelos Evangelou, Claudia P. Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P. Cook

MedicineScience And TechnologyHealthBiologyGenetics